We report specific heat and μSR measurements on Th and/or B substituted UBe13. The specific heat data show that either Th or B substitution reduces the Kondo temperature TK and increases the entropy at the superconducting transition by almost 20%, indicating an enhanced density of states. However, whereas μSR shows clear evidence for magnetic correlations for Th substitutions, no magnetism is observed for B substitutions. The enhanced specific heat jump in the B-substituted material is associated with a change in the (...) superconducting properties as TK is reduced. (shrink)

In both continental and analytical philosophy, social ontology has emerged as a particularly lively and increasingly sophisticated area of debate. This essay explores the potential contribution that social-ontological thinking can make to the continued development of critical theory via a critical reading of Georg Lukács and the Possibility of Critical Social Ontology – a collection of essays edited by Michael J. Thompson and published by Brill as part of the Studies in Critical Social Sciences series. The essay argues that (...) whilst social ontology as such no doubt offers a fruitful avenue for contemporary critical theory, the later philosophy of Georg Lukács represents an untenable and antiquated theoretical resource for such endeavours. The conceptual and systematic barriers to the revitalisation of the late Lukács are explored with specific reference to Lukács’ specific interpretation of the paradigm of labour and, closely related to this, his philosophy of history. (shrink)

Different explanations of color vision favor different philosophical positions: Computational vision is more compatible with objectivism (the color is in the object), psychophysics and neurophysiology with subjectivism (the color is in the head). Comparative research suggests that an explanation of color must be both experientialist (unlike objectivism) and ecological (unlike subjectivism). Computational vision's emphasis on optimally prespecified features of the environment (i.e., distal properties, independent of the sensory-motor capacities of the animal) is unsatisfactory. Conceiving of visual perception instead as the (...) visual guidance of activity in an environment that is determined largely by that very activity suggests new directions for research. (shrink)

The Mechanics of the Mind, in the words of its author, "is an attempt to interpret the phenomenon of mind in terms of the physiological processes of the nervous system and to explore the philosophical implications of a realistically conceived theory." The first four chapters of the book is little more than a survey of some neurophysiological, cognitive, psychosocial and clinical experimental data, the consideration of which presumably leads one to the conclusion that behavior is strictly neuronic. This extensive survey (...) of research data reads like a textbook in Introductory Psychology, for Lohr details experimental studies that are familiar to every college freshman. We hear once again of Kleitman’s sleep experiments, Harlow’s surrogate mothers, even Pavlov’s dogs. Yet, not only is this analysis boring, it is quite defective. Lohr relies solely on these classic experiments in order to argue his thesis; he seems largely to be ignorant of recent experimental research which directly affects his position. This fact is painfully evident both in his discussion of the Central Nervous System and in his treatment of clinical research. Concerning the CNS, Lohr does not take into account Moruzzi and Jouvet’s studies of the ARAS, the recent interest in the hippocampus and the work of Spencer, Thompson and Nielson on the neuronic basis of learning. Lohr’s clinical data are taken, almost exclusively, from the 1950 edition of Coleman’s textbook—an undergraduate primer in abnormal behavior. Yet, even if Lohr were conversant with recent physiological and clinical research it would be impossible to verify his conclusions independently since he provides not one footnote in 513 pages of technical discussion. There are occasional references to specific experiments but by author only; he does not offer dates or source of publication for any of the studies he cites. Moreover, Lohr provides no index and only a nominal bibliography whose omissions are more notable than its entries. These infractions of scholarly courtesy are, however, merely remote indications of the deeper difficulty. From his inadequate survey of experimental research Lohr concludes that an understanding of behavior as exclusively neuronic leads us back to "traditional values" once discarded by psychologists who thought their research explained away "innate tendencies." Lohr argues that "the institutions [i.e., social values] which have evolved do not reflect an artificial set of conditions imposed upon man." Rather, the shape of our nervous system forces upon us certain limits and therefore certain objective moral values. Physiological processes thus "determine" higher order behavior in that they provide an objective matrix from which certain kinds of behavior can be judged aberrant. Hence belief in God, and freedom of the will, insofar as these elements are entailed by objective moral standards, are respectable, even desirable, accoutrements of Lohr’s "mechanistic metaphysics." This reconstruction of morals on the basis of biology suggests a close parallel with certain 19th century evolutionist-philosophers, Spencer, Haeckel and Fiske being, perhaps, the most prominent of the school. These Victorian biologist-philosophers were much more certain of a direct link between neural processes and high-order behavior than their late 20th century counterparts, and they were much more liable to conflate possible social and cultural consequences of their work. Today, however, the type of connection between neural activity and higher order behavior is much less obvious due to more sophisticated research techniques and a more critical lay public. Lohr, as we have noted, does as little justice to these new techniques and trends as Spencer would have done. He completely ignores significant research and virtually all philosophical discussion concerning mind-brain identity. As a consequence, The Mechanics of the Mind fits the same genre as Spencer’s Synthetic Philosophy and Haeckel’s Riddle of the Universe—neither good science nor good philosophy.—J. F. (shrink)

Light effects on the activity of several genes have recently been exploited in studies of plant gene expression. We discuss here some examples involving nuclear genes of higher plants, with emphasis on responses mediated by the phytochrome system. Recent work has revealed considerable diversity in the responses of different genes, indicating that several different regulatory programs are probably involved. A start has been made in studies of nuclear events associated with the changes in expression. Transcriptional regulation almost certainly occurs, although (...) many details remain to be studied and effects on mRNA processing and turnover have not been ruled out. Recent in vitro mutagenesis and gene transfer experiments with the gene for the small subunit of RuBP carboxylase indicate that sequences involved in regulating the level of expression in the light are located 5′ to the gene within about 1 kb of the start of transcription. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

J. F. C. Harrison has written that ‘for each age there is a new view of Mr Owen’, which is proof of the fertility and continuing relevance of his ideas. Not just in Britain and America but today around the world anti-poverty campaigners, birth-controllers, collectivists, communitarians, co-operators, ecologists, educationalists, environmentalists, feminists, humanitarians, internationalists, paternalistic capitalists, secularists, campaigners for social justice, trade unionists, urban planners, utopians, welfare reformers can all find something to admire and inspire in the treasure trove that is (...) the thought and actions of Robert Owen. Owen was a creative genius of global significance, a radical writer and activist of international reputation and reach who has inspired those seeking to change human society for the better. The contributors to this volume include not only many of the recognized experts on the life, work and legacy of Owen, but also work from younger scholars or scholars coming to the field afresh. The volume presents the most recent and original research on Owen. Owen notoriously (and impressively) dabbled in many spheres, and this is reflected in the its breadth of content. The unifying themes are Owen’s profile in his own time, and the relevance of his ideas for the generations that followed. His importance for educational and social philosophy, for political economy and for the political theory of socialism are all discussed, as are his contribution as a philanthropic employer, his political activities and the specificities of his historical context. (shrink)

Parti INTRODUCTION Wittgenstein sometimes suggested looking on words as instruments, for example in the following passages from ...

Aristotle and the sea battle, by G. E. M. Anscombe.--Aristotle's different possibilities, by K. J. J. Hintikka.--On Aristotle's square of opposition, by M. Thompson.--Categories in Aristotle and in Kant, by J. C. Wilson.--Aristotle's Categories, chapters I-V: translation and notes, by J. L. Ackrill--Aristotle's theory of categories, by J. M. E. Moravcsik.--Essence and accident, by I. M. Copi.--Tithenai ta phainomena, by G. E. L. Owen.--Matter and predication in Aristotle, by J. Owens.--Problems in Metaphysics Z, chapter 13, by M. J. Woods.--The (...) meaning of agathon in the Ethics of Aristotle, by H. A. Prichard.--Agathon and eudaimonia in the Ethics of Aristotle, by J. L. Austin.--The final good in Aristotle's Ethics, by W. F. R. Hardie.--Aristotle on pleasure, by J. O. Urmson.--Bibliography (p. 335-41). (shrink)

Lanczos, C. Einstein's path from special to general relativity.--Balazs, N. L. The acceptability of physical theories: Poincaré versus Einstein.--Ellis, G. F. R. Global and non-global problems in cosmology, by G. F. R. Ellis and D. W. Sciama.--Ehlers, J. The geometry of free fall and light propagation, by J. Ehlers, F. A. E. Pirani and A. Schild.--Trautman, A. Invariance of Lagrangian systems.--Penrose, R. The geometry of impulsive gravitational waves.--Exact solutions of the Einstein-Maxwell equations for an accelerated charge.--Taub, A. H. Plane-symmetric similarity (...) solutions for self-gravitating fluids.--Robinson, I. Equations of motion in the linear approximation, by I. Robinson and J. R. Robinson.--Florides, P. W. Rotating bodies in general relativity.--Chandrasekhar, S. A limiting case of relativistic equilibrium.--Israel, W. The relativistic Boltzmann equation.--Thompson, W. B. The self-consistent test-particle approach to relativistic kinetic theory. (shrink)